Gulsevin Lab @ Butler University

Focus
The work in Gulsevin Lab. focuses on computational modeling of proteins involved in human health by incorporating experimental and genomic data into our computational analyses. We investigate how proteins, particularly membrane proteins, interact with their peptide and small molecule partners. Our work combines existing structural biology applications and methods developed in our group to explain how changes in structure and interactions of proteins affect human health.

Methods
We have a broad toolkit to investigate biological systems from a structural and functional perspective. We use traditional and state-of-the-art modeling tools including Rosetta, AlphaFold, RoseTTAFold, and molecular dynamics simulations to predict protein structures, investigate protein dynamics, and analyze interactions of proteins with their partners. We also develop methods and pipelines to predict protein – membrane and protein – peptide interactions.